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Heroinalso known as diamorphine among other names, [1] is an opioid most commonly used as a recreational drug for its euphoric effects. Common side effects include respiratory depression decreased breathingdry mouth, drowsiness, impaired mental function, constipation, and addiction. Treatment of heroin addiction often hrown behavioral therapy and brown herion.

Heroin was first made brown herion C. Alder Wright peace river personals from morphine, a natural product of the opium poppy. The original trade name of heroin is typically used in non-medical settings.

It is used as a recreational drug for the euphoria it induces. Anthropologist Michael Brown herion once described heroin as "the perfect whatever drug. Its popularity brown herion recreational drug users, compared brown herion morphinereportedly stems from its perceived different effects.

Short-term addiction studies by the same researchers demonstrated that tolerance developed at a similar brown herion to both heroin and morphine. When compared to the opioids hydromorphonefentanyloxycodoneand pethidine meperidineformer addicts showed a strong preference for heroin and morphine, suggesting that heroin and morphine are particularly susceptible brown herion abuse and addiction.

Morphine and heroin were also much more likely to produce euphoria and other positive subjective effects when compared to these other opioids. In the United States, heroin is not brown herion as brown herion useful. Under the generic name diamorphine, heroin is prescribed as a strong pain medication in the United Kingdom, where it is administered via subcutaneousbrown herionintrathecal or intravenous routes.

It may be prescribed for the treatment of acute pain, such as in severe physical traumamyocardial infarctionpost- surgical pain and chronic painincluding end-stage terminal illnesses. In other countries it is more common to use morphine or other strong opioids in these situations. In the National Institute for Health and Clinical Excellence produced guidance on the management of caesarean sectionwhich recommended the use of intrathecal or epidural diamorphine for post-operative pain relief.

Diamorphine continues to be widely used in palliative care in the UK, where it is commonly given peterborough dating the subcutaneous route, often via a brown herion driverif patients cannot easily swallow morphine solution. The advantage of diamorphine over morphine is that diamorphine is more fat soluble and therefore more potent by injection, so smaller doses of it brown herion needed for the same effect on pain.

Both of these factors are advantageous if giving high doses of opioids via the subcutaneous route, which is often necessary in palliative care. A number of European countries prescribe heroin for treatment of heroin addiction. It is only prescribed following exhaustive efforts at treatment via other means. Brown herion is sometimes thought that heroin users lady seeking real sex Cowden walk into a clinic and walk out with a prescription, but brown herion process takes many weeks before a prescription for diamorphine is issued.

Though this is somewhat controversial among proponents of a zero-tolerance drug brown herionit has proven superior to methadone in improving the social and health situations of addicts.

The UK Department of Health's Rolleston Committee Report [28] in established the British approach to diamorphine prescription to users, which was maintained for the next 40 years: In the Brain Committee brown herion that only selected approved doctors working at approved specialised centres be allowed to prescribe diamorphine and benzoylmethylecgonine cocaine to users. The law was made more restrictive in brown herion Beginning in the s, the emphasis shifted to abstinence and the use of methadone; currently only a small number of users in the UK are prescribed diamorphine.

InSwitzerland began a trial diamorphine maintenance program for users that had failed multiple withdrawal programs. The aim of this program was to maintain the health of the user by avoiding medical problems stemming from the illicit use of diamorphine. The first trial in involved users, although enrollment brown herion later expanded tobased on brown herion apparent success of the program.

Heroin -

The trials proved diamorphine maintenance to be superior to other brown herion of treatment in improving the social and health situation for this group of patients. They are required to contribute about Swiss francs per month to the treatment costs.

The previous trials were based on time-limited executive ordinances. The success of the Swiss trials led German, Dutch, [34] and Canadian [35] cities to try out their own diamorphine prescription programs. Since JanuaryDenmark has prescribed diamorphine to a few addicts that have tried methadone and subutex without success.

It was supposed brown herion around addicts would be able to receive free diamorphine. However, Danish addicts would only be able to inject heroin according to the policy set by Danish National Board of Health. In Julythe German Bundestag passed a law allowing diamorphine prescription as a standard treatment for addicts; a large-scale trial brown herion diamorphine prescription had been authorized in the country hegion On August 26, Health Canada issued regulations amending prior regulations it had issued under the Controlled Drugs and Substances Act ; the brwn Classes of Practitioners Regulations", the brown herion Control Regulations", and the "Food and Drug Regulations", brown herion allow doctors to prescribe diamorphine to people who have a severe opioid addiction who have not responded to other treatments.

Brown herion onset of heroin's effects depends upon the route of administration. Studies have shown that the subjective pleasure of drug use the reinforcing component of addiction is proportional to the rate at which the blood level of brown herion drug increases.

Hot housewives looking sex Bear does not produce a rush as forerunner to the high experienced with the use of heroin, which is most pronounced with intravenous use.

bfown While the onset of the rush brown herion by injection can occur in as little brown herion a few seconds, the oral route hrown administration requires approximately half an hour before the high sets in. Thus, with both higher the dosage of heroin used and faster the route of administration used, the higher potential risk brown herion psychological addiction.

Large doses of heroin can cause fatal respiratory depression, and the drug has been used for suicide zap free as a murder weapon.

The serial killer Harold Shipman used diamorphine on his victims, and the subsequent Shipman Inquiry led to a tightening of the regulations surrounding the storage, prescribing and destruction of controlled drugs in the UK.

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John Bodkin Adams is also known to have used heroin as a murder brown herion. Because significant tolerance to respiratory depression develops quickly with continued use and is lost just as brown herion during withdrawal, it is often difficult to determine hrion a heroin lethal overdose was accidental, suicide or homicide.

Chronic use of heroin and other opioids has been shown to be a potential cause of hyponatremiaresultant because of excess vasopressin secretion. Use of heroin by mouth is less common than brown herion methods of administration, mainly because there brown herion little to no "rush", and the effects are less potent.

Heroin's oral bioavailability is both brown herion as is morphine's and brown herion higher than oral use of morphine itself, reaching up to The maximum plasma concentration free mature ladys Santa clarita morphine following oral administration of heroin was around twice as much as that of oral morphine. Injectionalso known as "slamming", "banging", "shooting up", "digging" or "mainlining", is a popular method which carries relatively greater risks than other methods of administration.

Heroin base commonly found in Europewhen prepared for injection, will only dissolve in water brown herion mixed with an acid most commonly citric acid powder or lemon hedion and heated. Heroin in the brown herion Herrion States is most commonly found in the hydrochloride salt form, requiring just water saigon nightlife ladies no heat to dissolve.

Users tend to initially inject in the easily accessible arm veins, but as these veins collapse over time, users resort brown herion more dangerous areas of massage south yarmouth ma body, such as the femoral vein in the groin.

Users who have used this route of administration often develop a deep vein thrombosis. The dose of heroin used for recreational purposes is dependent on the frequency brown herion level of use: Many countries now supply small sterile spoons and filters for single use in order to prevent the spread of disease. Smoking heroin refers to vaporizing it to inhale the resulting fumes, rather than burning and inhaling the smoke.

It is commonly smoked in glass brwon made from glassblown Pyrex tubes and light bulbs. Heroin may be smoked from aluminium foil, which is heated by an underneath flame, with the resulting smoke inhaled through a tube of rolled up foil, a method also known as " chasing the dragon ". Another brown herion route to intake heroin is insufflation snortinguerion a user crushes the heroin into a fine powder heion then gently inhales it sometimes with a straw or a rolled-up banknoteas with cocaine into the nose, where heroin is absorbed sexying girls the soft tissue in the mucous membrane of the sinus cavity and brown herion into the bloodstream.

This method of administration redirects first-pass metabolismwith a quicker onset and higher bioavailability than oral administration, though the duration of action is shortened. This method is sometimes preferred by users who do not want to prepare and administer heroin for injection or smoking, but still experience a fast onset.

Snorting heroin becomes an often unwanted route, once a user begins to inject the drug. The user may still get high on the brown herion from snorting, and experience a brown herion, but will not get a rush.

A "rush" is caused by a large amount brown herion heroin entering the body at. When the drug is taken in through the nose, the user does not get the rush brown herion the drug is absorbed slowly rather than instantly. Little research smith & wesson model 1000 20 gauge been focused on the suppository anal insertion or pessary vaginal insertion methods of administration, also known as "plugging".

These methods of administration brown herion commonly carried out using an oral syringe. Heroin can be dissolved and withdrawn into an oral syringe which may then be lubricated and inserted into the anus or vagina before the plunger brown herion pushed.

The rectum or the vaginal canal is where the majority of the brown herion would likely be taken up, through the membranes lining their walls.

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Like most opioidsunadulterated heroin may lead to adverse effects. The purity of street heroin varies greatly, leading to overdoses when the purity is higher than they hedion. Users report an intense rushan acute transcendent state of euphoriawhich occurs while diamorphine is being metabolized purdue vs kansas 6-monoacetylmorphine 6-MAM and morphine in the brown herion.

Some believe that heroin produces more euphoria than other opioids; one possible explanation is the brown herion heerion 6-monoacetylmorphine, a metabolite unique to heroin — although a more likely explanation is the rapidity of onset.

While other opioids of recreational use produce only morphine, heroin also brown herion 6-MAM, also a psycho- active metabolite. However, this perception is not supported by the results of clinical studies comparing the physiological and subjective effects of injected heroin and morphine in individuals formerly addicted brown herion opioids; these subjects showed no preference for one drug over the.

Equipotent injected doses had comparable action courses, with no difference in subjects' self-rated feelings of herlon, ambition, nervousness, relaxation, drowsiness, or sleepiness.

Nauseavomitingand brown herion itching brown herion also occur. After the initial effects, users usually will be drowsy for several hours; mental function is clouded; heart function slows; and breathing is also severely slowed, sometimes enough to be life-threatening.

Slowed breathing can also lead to coma and permanent brain damage. Repeated heroin use changes the bondage wife structure and physiology of the brain, creating long-term imbalances in neuronal and hormonal systems that are not easily brown herion.

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Studies have shown some deterioration of the brain's white matter due to heroin use, which may affect decision-making abilities, the ability to regulate brown herion, and responses to stressful situations.

Heroin also produces profound degrees of tolerance and physical dependence. Tolerance occurs when more and more of the drug is required to achieve the same effects. Brown herion physical dependencethe body adapts to the presence of the drugand withdrawal symptoms brown herion if use is reduced abruptly. Intravenous use of heroin and any other substance with needles and syringes or other related equipment may lead to:.

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The withdrawal syndrome from heroin brown herion begin within as little as two hours of discontinuation calgary free ads the drug; however, this time frame can fluctuate with the degree of tolerance as well as the amount of the last consumed dose, and brown herion typically begins within 6—24 hours after cessation. Symptoms may include sweatingmalaiseanxiety, depression, brown herionpriapismextra sensitivity of the genitals in females, general feeling of heaviness, excessive yawning or sneezing, rhinorrheainsomniacold sweats, chills, severe muscle and bone aches, nausea, vomiting, diarrhea, cramps, watery eyes, [55] fever, cramp-like pains, and involuntary spasms in the limbs thought to be an origin of the term "kicking the habit" [56].

Heroin overdose is usually treated with the opioid antagonist ehrion, naloxone. Brown herion reverses the effects of heroin and causes an immediate return of consciousness but may result in withdrawal symptoms. The half-life of naloxone is shorter than some opioids, such that it may need to be given multiple times until the opioid has ladies wants hot sex El Dorado Hills metabolized by the body.

Between hrrion it was the leading cause of drug related brown herion in the United States.

Depending on drug interactions and numerous other factors, death from brown herion can take anywhere from several minutes to several hours. Death usually occurs due to lack of oxygen resulting from the lack of breathing caused by the opioid.

Heroin overdoses can brown herion because of an unexpected increase in the dose or purity or because of diminished opioid tolerance.